Notch signaling in thyrocytes is essential for adult thyroid …
Dec 20, 2023 · We discover two thyrocyte subtypes in mouse and human thyroids, identified in single-cell analyses by different levels of metabolic activity and Notch signalling.
Adult mouse and human organoids derived from thyroid ... - PubMed
Dec 21, 2021 · The thyroid maintains systemic homeostasis by regulating serum thyroid hormone concentrations. Here we report the establishment of three-dimensional (3D) organoids from adult thyroid tissue representing murine and human thyroid follicular cells (TFCs).
Adult mouse and human organoids derived from thyroid …
Dec 12, 2021 · Based on our previously described 3D culturing conditions of long-term expansion of mouse and human organoids from a variety of other tissues, we dissected and minced thyroid tissue, incubated the fragments in digestion solution, and plated thyroid cells in basement membrane extract (BME).
Insight Into Mouse Models of Hyperthyroidism - PMC
Jun 22, 2022 · Various mouse models have been used to investigate hyperthyroidism . Researchers have carried out immunization approaches, such as injecting the adenovirus or plasmid accompanied by thyroid stimulating hormone receptor (TSHR), or chemical methods, such as levothyroxine supplementation (5–7).
Mouse Models of Thyroid Cancer: A 2015 Update - PMC
There are currently multiple mouse models of BRAF activation, and the overall picture is highly consistent across models. The most straightforward model is a transgenic line targeting of BRAF V600E to the thyroid by the use of the bovine thyroglobulin (Tg) promoter (Knauf, Ma, …
Transplantable human thyroid organoids generated from …
Nov 17, 2022 · Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of...
An in vivo model for thyroid regeneration and folliculogenesis
Jun 26, 2018 · In mouse thyroids, a cluster of cells are found near the tracheal cartilage and muscle, which are positive for expression of NKX2-1, the master transcription factor governing thyroid development...
Genetically modified mouse models to investigate thyroid
Here, we will present an overview of genetic mouse models for thyroid diseases, which have provided crucial insights into thyroid gland development, function, and growth with a special focus on TSHR and microRNA signaling.
Morphological and Functional Changes in the Thyroid Follicles of …
Jul 19, 2016 · Thyroid follicles of aged mice and women show characteristic morphological changes, such as cystic atrophy, empty colloid, and Tg globules. Keywords: Aged, Elderly, Thyroid gland, Thyroid hormones. The functional unit of the thyroid gland is the thyroid follicle, which is composed of follicular cells and intrafollicular colloid.
Thyroid hormone as a temporal switch in mouse development
open access. Thyroid hormones are known to trigger metamorphosis in an amphibian. This review discusses the hypothesis according to which they act in a similar manner to synchronize the post-natal development of mice, using brain, brown adipose tissue, and heart as examples. Previous. Next. thyroid hormone. mouse. postnatal development.