An overview of microRNAs: Biology, functions, therapeutics, and ...
WEBMicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis.
The discovery of microRNA wins the 2024 physiology Nobel Prize
WEB1 day ago · Victor Ambros (left) and Gary Ruvkun (right) won the 2024 Nobel Prize in physiology or medicine for the discovery of microRNA and its role in gene regulation. An unexpected discovery about what ...
microRNAs in action: biogenesis, function and regulation
WEBJun 28, 2023 · In this Review, the authors describe how the application of new technologies to the microRNA (miRNA) field has yielded key insights into miRNA biology.
Overview of MicroRNA Biogenesis, Mechanisms of Actions, …
WEBAug 3, 2018 · In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. We also summarize the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs.
Nobel Prize in Physiology or Medicine Honors Ambros and …
WEB1 day ago · Treatments based on microRNA are in clinical trials for heart disease, cancer and neurodegenerative disease. ... is often explained to high school biology students as carrying instructions from ...
MicroRNAs: From Mechanism to Organism - Frontiers
WEBJun 2, 2020 · MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors of gene expression in diverse biological contexts.
MicroRNA - an overview | ScienceDirect Topics
WEBMicroRNAs are short RNA molecules of about 22 nucleotides that regulate gene expression by binding to mRNA, leading to silencing or degradation of the target mRNA. They play critical roles in various biological processes and are abundantly present in all human cells, controlling cellular functions like proliferation, differentiation, and apoptosis.
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and ... - PubMed
WEBAug 3, 2018 · MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary miRNAs and processed into …
Regulation of microRNA biogenesis | Nature Reviews Molecular Cell Biology
WEBJul 16, 2014 · MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Biogenesis of miRNA is under tight temporal and spatial control. Dysregulation of...
Regulation of microRNA function in animals - Nature
WEBAug 14, 2018 · MicroRNAs (miRNAs) are short non-coding RNAs (ncRNAs) of ~22 nucleotides that mediate gene silencing by guiding Argonaute (AGO) proteins to target sites in the 3′ untranslated region (UTR) of...