The Gunners are undefeated to start the season and are just one point behind league leaders Liverpool, very much on the opposite end of the table as their opponents. Southampton have just one point from six games and sit in 19th place, marking an unpleasant start to their rerun to the top flight.

Raheem Sterling has been handed his first Premier League start since joining Arsenal in the summer from local rivals Chelsea. Jurrien Timber, who limped off against Paris Saint-Germain has not been deemed fit enough to make the matchday squad.