It's time to start the conversation, after the Chiefs defeated the 49ers on the road in Week 7. Can Mahomes & Co. pull off the unlikely? Check out the odds.

Kansas City (5-0) takes a five-game winning streak into a matchup with San Francisco on Sunday, October 20, 2024 at Levi’s Stadium. The line predicts a close game, with the 49ers favored by

This will be the teams’ fourth meeting in the past six seasons – they have also played in two of the past five Super Bowls – and the Chiefs have won each of the previous matchups. Kansas City rallied to knock off San Francisco in overtime, 25-22, to win its second straight Super Bowl in February.