Discovered in 1997, backtracking is a process in which RNA polymerase, instead of moving forward along the DNA as it reads a gene, shifts back and pauses. This halt then resolves and the enzyme can ...

In 1997, Evgeny Nudler, Ph.D. and colleagues published a paper that showed RNA polymerase can sometimes slip backward along the chain it is reading, a phenomenon they named "backtracking." ...

RNA polymerase is an enzyme that is responsible for copying a DNA sequence into an RNA sequence, duyring the process of transcription. As complex molecule composed of protein subunits, RNA ...

Three different types of RNA polymerase exist in eukaryotic cells, whereas bacteria have only one. In eukaryotes, RNA pol I transcribes the genes that encode most of the ribosomal RNAs (rRNAs ...

Herman Lab research can be most easily divided into three major domains, with each member of the lab more or less specializing in one for their project: It’s known that the genome stability of a cell ...

Xia J, Chiu LY, Nehring RB, Bravo Núñez MA, Mei Q, Perez M, Zhai Y, Fitzgerald DM, Pribis JP, Wang Y, Hu CW, Powell RT, LaBonte SA, Jalali A, Matadamas Guzmán ML ...

Our interest in transcription regulation is to understand the mechanism of transcription initiation by bacterial and archaeal RNA polymerases. Our primary focus in sensor research is to develop robust ...

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

Long known as a messenger within cells, RNA is increasingly seen as life’s molecular communication system — even between organisms widely separated by evolution. For a molecule of RNA, the world is a ...

This unwinding of the helix is caused by an enzyme (helicase enzyme). The enzyme RNA polymerase attaches to the DNA in a non-coding region just before the gene. RNA polymerase moves along the DNA ...

Vice President Kamala Harris said in Tuesday’s debate with former President Donald Trump she has been against a fracking ban since 2020—but her messaging on the issue has been less clear than ...

Several antiviral and anticancer drugs target the incorporation of adenine into DNA or RNA. For example, some nucleoside analog drugs, such as vidarabine and fludarabine, mimic adenine and interfere ...