Furthermore, new exons can be inserted into old introns, creating new proteins without disrupting the function of the old gene. Our knowledge of RNA splicing is quite new. Nonetheless, because ...

The study, published this week in Nature Genetics, shows that the biggest impact of alternative splicing may come via its role in regulating gene expression levels. The research team, led by Yang Li, ...

Once the target gene is cleaved, the ribozyme-derived hybridization motif binds, and RNA splicing leads to the formation of a wild-type copy of the mature mRNA. Many of these RNA-based strategies ...

Researchers in the U.K. have succeeded in reverse engineering the defective cryptic splicing that drives amyotrophic lateral ...

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the ...

This study lays the groundwork for further exploration into the complex interplay between gene expression, splicing, and metabolic regulation." The study's implications extend across agriculture ...

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the ...

Victor Ambros and Gary Ruvkun win 2024 Nobel Prize for their groundbreaking discovery of microRNA's role. Recognised by ...

Within a gene, there are coding regions called exons, which contain the information for protein synthesis, and non-coding regions called introns, which are removed during the process of RNA splicing ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript abundances. One area of increasing interest is alternative splicing ...

“The trans-splicing ribozyme recognizes and cleaves the hTERT mRNA, and it replaces the hTERT mRNA with Herpes Simplex Virus thymidine kinase, which is used as a suicide gene. With the co ...

Nobel Prize in Physiology or Medicine was awarded jointly to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in regulation.