microRNAs in action: biogenesis, function and regulation
WEBJun 28, 2023 · Accessory factors can regulate microprocessing of pri-miRNA, including binding of CNNC by SRSF3. pri-miRNAs with suboptimal features such as missing motifs, an unpaired lower stem and/or small...
MicroRNAs and their targets: recognition, regulation and an
WEBMar 13, 2012 · Coding and non-coding RNAs can function as competing endogenous RNAs (ceRNAs) that bind miRNAs, sequestering them from binding and regulating other RNAs. miRNA 'sponges' have been engineered to...
The MicroRNA (miRNA): Overview of the RNA Genes that …
WEBNov 13, 2007 · The microRNA (miRNA) is a form of small, single-stranded RNA, 18–25 nucleotides long. It is transcribed from DNA, instead of being translated into protein, and regulates the functions of other genes in protein synthesis. Therefore, miRNAs are genes that modulate other protein-coding genes.
Origins and Mechanisms of miRNAs and siRNAs - PMC - National …
WEBFeb 2, 2009 · Two primary categories of these small RNAs— short interfering RNAs (siRNAs) and microRNAs (miRNAs)—act in both somatic and germline line-ages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids.
microRNA-binding proteins: specificity and function - PubMed
WEBmicroRNA (miRNA) and RNA-binding proteins (RBPs) have been studied widely in post-transcriptional gene regulation. Previous work has focused on defining how miRNA and RBPs modulate target mRNA decay and translation as well as investigating how they interplay each other.
Overview of MicroRNA Biogenesis, Mechanisms of Actions, …
WEBAug 3, 2018 · In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. We also summarize the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs.
Regulation of microRNA biogenesis - Nature Reviews Molecular …
WEBJul 16, 2014 · MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Biogenesis of miRNA is under tight temporal and spatial control. Dysregulation of miRNA is...
miRDB - MicroRNA Target Prediction Database
WEBCommon features associated with miRNA binding and target downregulation have been identified and used to predict miRNA targets with machine learning methods. miRDB hosts predicted miRNA targets in five species: human, mouse, rat, dog and chicken.
Prediction of functional microRNA targets by integrative …
WEBJan 22, 2019 · This RNA-seq dataset is combined with public miRNA target binding data to systematically identify miRNA targeting features that are characteristic of both miRNA binding and target downregulation.
miRBind: A Deep Learning Method for miRNA Binding …
WEBDec 9, 2022 · The binding of microRNAs (miRNAs) to their target sites is a complex process, mediated by the Argonaute (Ago) family of proteins. The prediction of miRNA:target site binding is an important first step for …