RNA editing - Wikipedia
WEBRNA editing (also RNA modification) is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase.
Precision RNA base editing with engineered and endogenous …
WEBSep 21, 2023 · In this Review, we summarize current site-directed RNA base-editing strategies and highlight recent achievements to improve editing efficiency, precision, codon-targeting scope and in vivo...
Understanding RNA editing and its use in gene editing
WEBDec 1, 2022 · This review summarizes our current understanding of RNA editing in various organisms especially focusing on C-to-U and U-to-C RNA editing in plants and pentatricopeptide repeat (PPR) proteins that are responsible for target RNA recognition and editing reactions.
6.5: RNA Editing - Biology LibreTexts
WEBMay 15, 2022 · RNA editing occurs by two distinct mechanisms: Substitution Editing: chemical alteration of individual nucleotides (the equivalent of point mutations). These alterations are catalyzed by enzymes that recognize a specific target sequence of nucleotides (much like restriction enzymes): cytidine deaminases that convert a C in the RNA to uracil (U);
Move over, CRISPR: RNA-editing therapies pick up steam - Nature
WEBFeb 16, 2024 · RNA-editing techniques aim to compensate for harmful mutations by changing the sequence of RNA, allowing normal proteins to be synthesized. RNA editing can also increase the production of...
RNA editing - Latest research and news - Nature
WEBAug 5, 2024 · RNA editing is the process by which ribonucleic acid (RNA) molecules are enzymatically modified post synthesis on specific nucleosides. Examples of RNA editing include pseudouridylation...
RNA editing with CRISPR-Cas13 | Science - AAAS
WEBOct 25, 2017 · Efficient and precise RNA editing to correct disease-relevant transcripts holds great promise for treating genetic disease. Cox et al. took advantage of the ability of Cas13b, an effector from a type VI CRISPR-Cas system, to target specific RNAs directly (see the Perspective by Yang and Chen). They fused Cas13b with the ADAR2 adenosine ...
RNA editing enzymes: structure, biological functions and …
WEBMar 16, 2024 · There are two main types of RNA editing events: adenosine to inosine (A-to-I) editing, catalyzed by ADARs on double-stranded RNA or ADATs on tRNA, and cytosine to uridine (C-to-U) editing catalyzed by APOBECs. This article provides an overview of the structure, function, and applications of RNA editing enzymes.
RNA Editing - an overview | ScienceDirect Topics
WEBRNA editing is an epigenetic mechanism that is responsible for RNA post-transcriptional processing (Mehler and Mattick, 2007). It promotes the generation of significant molecular diversity and environmental plasticity in transcripts through directed modification of nucleotides in RNA molecules.
RNA editing: new roles in feedback and feedforward control
WEBJun 12, 2023 · RNA editing represents a form of RNA metabolism that alters transcript sequences without changing DNA sequences, and ADAR-catalyzed A-to-I RNA editing is the most common RNA editing...