CDD Conserved Protein Domain Family: Phlebovirus_G2
WEBSep 29, 2021 · Phlebovirus glycoprotein G2. This family consists of several Phlebovirus glycoprotein G2 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex.
The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly …
WEBJul 21, 2016 · In particular, the finding that phlebovirus Gc proteins are class II viral membrane fusion proteins provided important insights into the membrane fusion reaction and imaging approaches allowed to elucidate the cell biology of phlebovirus entry.
Genus: Phlebovirus | ICTV
WEBEighty-two species for 98 viruses are assigned to the genus Phlebovirus. The phlebovirus genome encompasses three single-stranded RNA segments, encoding four structural proteins: a large protein (L), two external glycoproteins (Gn and Gc) and a nucleocapsid protein (N), as well as two non-structural proteins (NSm and NSs).
Phlebovirus - Wikipedia
WEBPhleboviruses are viruses with a negative-sense RNA genome consisting of three segments. The small segment (S) codes for the viral N protein and a non structural protein, NSs via an ambisense coding strategy. The medium-sized segment (M) codes for a precursor of the viral glycoproteins and non-structural components.
Structures of phlebovirus glycoprotein Gn and identification …
WEBSep 5, 2017 · Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus (RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause severe illness in humans and animals. Glycoprotein N (Gn) is one of the envelope proteins on the virus surface and is a major antigenic component.
Structure of a phleboviral envelope glycoprotein reveals a consolidated ...
WEBJun 28, 2016 · These data provide structural and functional evidence that the mechanism of phlebovirus-host cell fusion is conserved among genetically and patho-physiologically distinct viral pathogens. Keywords: bunyavirus; emerging virus; phlebovirus; structure; viral membrane fusion.
Molecular Biology of Phleboviruses | SpringerLink
WEBThe Phlebovirus genus encompasses two groups of viruses, the phlebotomus or sandfly fever group (PHL) and the Uukuniemi group (Calisher, 1991). In a previous taxonomic organization the two groups, based on serological relationships, were …
The Severe Fever with Thrombocytopenia Syndrome Virus NSs …
WEBFeb 28, 2020 · Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified phlebovirus associated with severe hemorrhagic fever in humans. While many viruses subvert the host cell cycle to promote viral growth, it is unknown whether this is a strategy employed by SFTSV.
Phlebovirus - an overview | ScienceDirect Topics
WEBPhlebovirus contains 37 viruses, most of which have phlebotomine sand fly vectors. It also includes the important mosquito-borne Rift Valley Fever virus.
Pfam: Family: Phlebovirus_G2 (PF07245)
WEBThis family consists of several Phlebovirus glycoprotein G2 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi [ 1 ].
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