Oligonucleotide - Wikipedia
WEBOligonucleotides are characterized by the sequence of nucleotide residues that make up the entire molecule. The length of the oligonucleotide is usually denoted by "-mer" (from Greek meros, "part"). For example, an oligonucleotide of six nucleotides (nt) is a hexamer, while one of 25 nt would usually be called a "25-mer".
What is an Oligonucleotide? - News-Medical.net
WEBJul 20, 2023 · Oligonucleotides are short nucleic acid polymers used in research, genetic testing and forensics. Oligonucleotides are usually made up of 13 to 25 nucleotides and are designed to hybridize ...
Oligonucleotide - an overview | ScienceDirect Topics
WEBAn oligonucleotide is defined as a short DNA or RNA molecule, either single- or double-stranded, which includes antisense oligonucleotides, RNA interference, and aptamer RNAs. These molecules are used to modulate gene and protein expression and can accumulate in various tissues after administration.
What is an Oligo? - Thermo Fisher Scientific
WEBSep 19, 2019 · Oligonucleotides, or oligos, are short single strands of synthetic DNA or RNA that serve as the starting point for many molecular biology and synthetic biology applications! From genetic testing to forensic research and next-generation sequencing, an oligo may very well be the starting point.
Oligonucleotide | Description, Characteristics, Functions, & Facts ...
WEBAn oligonucleotide is a short chain of nucleotides (nitrogen-containing units linked to a sugar and a phosphate group) that consist of either single- or double-stranded DNA or RNA.
Advances in oligonucleotide drug delivery - Nature
WEBAug 11, 2020 · Here, we provide an overview of oligonucleotide-based drug platforms, focusing on key approaches — including chemical modification, bioconjugation and the use of nanocarriers — which aim to ...
Oligonucleotide Definition and Examples - Biology Online
WEBJun 24, 2021 · An oligonucleotide is a compound comprised of about three to twenty nucleotides. Each monomeric unit component is comprised of a nucleobase, a pentose moiety, and phosphate group. Oligonucleotides are short DNA or RNA molecules.
Oligonucleotide Therapeutics: From Discovery and Development …
WEBOligonucleotide therapeutics are generally used to (i) induce the degradation of an mRNA or non-coding RNA, (ii) inhibit the translation of an mRNA, (iii) induce splice switching, or (iv) activate the transcription of a gene (saRNA).
Oligonucleotide - an overview | ScienceDirect Topics
WEBASO and RNAi oligonucleotides are intended mainly for modulating gene and protein expression. Aptamer oligonucleotides can act as “chemical antibodies” to modulate functions of proteins and other macromolecules. The main safety concern for oligonucleotides is their exaggerated pharmacologic effects.
Oligonucleotide - an overview | ScienceDirect Topics
WEBOligonucleotides are short single-stranded segments of DNA or RNA that, upon cellular internalization, can selectively inhibit the expression of a single protein.86 Multiple forms of oligonucleotides are used in gene therapy, including antisense, siRNA, and ribozymes.
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